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Women who fail to respond to, or stop taking, their medication to fight the bone-thinning condition osteoporosis are at high risk of suffering a bone fracture, a new study suggests.

British researchers found that among nearly 2,000 older women with an “inadequate response” to osteoporosis medication, 9 percent suffered a fracture over the next year.

Those who’d had a fracture in the past were at particular risk, according to findings published in the journal Osteoporosis International.

The researchers considered two groups of women as having an inadequate response to drug therapy: those who, before the study period, had suffered a bone break despite being on osteoporosis medication for at least one year; and those who had stopped taking their medication because of side effects or difficulty sticking with the regimen.

While some women in each group suffered a bone break over the next year, the risk was nearly twice as high among women with a past fracture.

Suffering a new fracture took a toll on the women’s quality of life, with many reporting pain, discomfort and problems with their normal daily activities.

In general, health-related quality of life among all women who suffered a fracture was far lower than the norm for women their age, according to the researchers, led by Dr. Cyrus Cooper of Southampton General Hospital in the UK.

Women who don’t benefit from osteoporosis treatment, or who stop taking the medication, need to be aware of their fracture risk and get further evaluation and treatment, Cooper told Reuters Health.

Past studies have found that up to half of women on osteoporosis medication stop taking the drugs within one year, often because of side effects.

Side effects depend on the type of medication. With the group of drugs known as bisphosphonates the more common side effects include stomach upset, heartburn, and joint, muscle or abdominal pain.

The drug raloxifene, can cause hot flashes and raise the risk of blood clots in the legs. Enhancing better compliance is key to the effectiveness of preventive strategies against fractures.

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