Lipitor

Cholesterol

AHA Scientific Position
Cholesterol is a soft, waxy substance found among the lipids (fats) in the bloodstream and in all your body’s cells. It’s an important part of a healthy body because it’s used to form cell membranes, some hormones and is needed for other functions. But a high level of cholesterol in the blood — hypercholesterolemia — is a major risk factor for coronary heart disease, which leads to heart attack.

Cholesterol and other fats can’t dissolve in the blood. They have to be transported to and from the cells by special carriers called lipoproteins. There are several kinds, but the ones to focus on are low-density lipoprotein (LDL) and high-density lipoprotein (HDL).

What is LDL cholesterol?

Low-density lipoprotein is the major cholesterol carrier in the blood. If too much LDL cholesterol circulates in the blood, it can slowly build up in the walls of the arteries feeding the heart and brain. Together with other substances it can form plaque, a thick, hard deposit that can clog those arteries. This condition is known as atherosclerosis. A clot (thrombus) that forms near this plaque can block the blood flow to part of the heart muscle and cause a heart attack. If a clot blocks the blood flow to part of the brain, a stroke results. A high level of LDL cholesterol (160 mg/dL and above) reflects an increased risk of heart disease. If you have heart disease, your LDL cholesterol should be less than 100 mg/dL and your doctor may even set your goal to be less than 70 mg/dL. That’s why LDL cholesterol is called “bad” cholesterol. Lower levels of LDL cholesterol reflect a lower risk of heart disease.

What is HDL cholesterol?

About one-third to one-fourth of blood cholesterol is carried by HDL. Medical experts think HDL tends to carry cholesterol away from the arteries and back to the liver, where it’s passed from the body. Some experts believe HDL removes excess cholesterol from plaques and thus slows their growth. HDL cholesterol is known as “good” cholesterol because a high HDL level seems to protect against heart attack. The opposite is also true: a low HDL level (less than 40 mg/dL in men; less than 50 mg/dL in women) indicates a greater risk. A low HDL cholesterol level also may raise stroke risk.

What is Lp(a) cholesterol?

Lp(a) is a genetic variation of plasma LDL. A high level of Lp(a) is an important risk factor for developing atherosclerosis prematurely. How an increased Lp(a) contributes to heart disease isn’t clear. The lesions in artery walls contain substances that may interact with Lp(a), leading to the buildup of fatty deposits.

What about cholesterol and diet?

People get cholesterol in two ways. The body — mainly the liver — produces varying amounts, usually about 1,000 milligrams a day. Foods also can contain cholesterol. Foods from animals (especially egg yolks, meat, poultry, shellfish and whole- and reduced-fat milk and dairy products) contain it. Foods from plants (fruits, vegetables, grains, nuts and seeds) don’t contain cholesterol.

Typically the body makes all the cholesterol it needs, so people don’t need to consume it. Saturated fatty acids are the main culprit in raising blood cholesterol, which increases your risk of heart disease. Trans fats also raise blood cholesterol. But dietary cholesterol also plays a part. The average American man consumes about 337 milligrams of cholesterol a day; the average woman, 217 milligrams.

Some of the excess dietary cholesterol is removed from the body through the liver. Still, the American Heart Association recommends that you limit your average daily cholesterol intake to less than 300 milligrams. If you have heart disease, limit your daily intake to less than 200 milligrams. Still, everyone should remember that by keeping their dietary intake of saturated and trans fats low, they can significantly lower their dietary cholesterol intake. Foods high in saturated fat generally contain substantial amounts of dietary cholesterol.

People with severe high blood cholesterol levels may need an even greater reduction. Since cholesterol is in all foods from animal sources, care must be taken to eat no more than six ounces of lean meat, fish and poultry per day and to use fat-free and low-fat dairy products. High-quality proteins from vegetable sources such as beans are good substitutes for animal sources of protein.

How does physical activity affect cholesterol?

Regular physical activity increases HDL cholesterol in some people. A higher HDL cholesterol is linked with a lower risk of heart disease. Physical activity can also help control weight, diabetes and high blood pressure. Aerobic physical activity raises your heart and breathing rates. Regular moderate-to-vigorous-intensity physical activity such as brisk walking, jogging and swimming also condition your heart and lungs.

Physical inactivity is a major risk factor for heart disease. Even moderate-intensity activities, if done daily, help reduce your risk. Examples are walking for pleasure, gardening, yard work, housework, dancing and prescribed home exercise.

How does tobacco smoke affect cholesterol?

Tobacco smoke is one of the six major risk factors of heart disease that you can change or treat. Smoking lowers HDL cholesterol levels and increases the tendency for blood to clot.

How does alcohol affect cholesterol?

In some studies, moderate use of alcohol is linked with higher HDL cholesterol levels. However, because of other risks, the benefit isn’t great enough to recommend drinking alcohol if you don’t do so already.

If you drink, do so in moderation. People who consume moderate amounts of alcohol (an average of one to two drinks per day for men and one drink per day for women) have a lower risk of heart disease than nondrinkers. However, increased consumption of alcohol brings other health dangers, such as alcoholism, high blood pressure, obesity, stroke, cancer, suicide, etc. Given these and other risks, the American Heart Association cautions people against increasing their alcohol intake or starting to drink if they don’t already do so. Consult your doctor for advice on consuming alcohol in moderation.

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Six Common Myths You Should Know To Protect Your Heart

February is National Heart Month, a time to raise awareness about heart disease, which remains the leading cause of death for American men and women.

Ask yourself if you’re taking care of your heart, and do not be fooled by these common myths.

Myth 1
If I exercise and maintain a healthy lifestyle, I will not get heart disease. — False

Eating healthy and exercising is a great start, but does not guarantee health.

Risk of heart disease increases with several uncontrollable factors: You are more at risk if you are a man, if you are older and if you have a genetic history of diabetes, high cholesterol or high blood pressure.

It is important to follow up with your doctor at least once a year to test your blood pressure and cholesterol levels, even in your 20s.

If you are predisposed to high blood pressure or high cholesterol, you may need to take medication to prevent heart disease.

Myth 2
I won’t have to worry about heart disease until I’m much older. — False

Coronary artery disease can start to develop in our teenage years, and many of the bad habits we develop as young adults persist as we get older.

Children who are obese, have high blood pressure and a family history of heart disease are at higher risk.

Although rare, some children (usually due to genetic differences) can have unusually high cholesterol and thus an increased risk for heart disease.

Myth 3
A little bit of alcohol is good for the heart. — True

Recent studies show a small amount of alcohol every day, such as one glass of wine or a little bit more, can actually be beneficial for the heart.

There is debate as to what type of alcohol is best. There are benefits associated with red wine, but other types may be beneficial as well.

Too much alcohol can pose problems though. Binge drinking on weekends, for example, can be very damaging to the heart. Alcohol in large amounts has a toxic effect on the heart muscle cells, and can lead to heart failure.

Myth 4
If I have two scrambled eggs for breakfast, I’ve already exceeded my daily recommended cholesterol intake. — True.

A typical egg yolk has about 200 to 250 milligrams of cholesterol (of course, there is no cholesterol in egg whites). The recommended daily cholesterol intake, according to the American Heart Association, is 300 milligrams a day.

If you eat two egg yolks for breakfast, you are likely exceeding your daily recommended intake by more than one-third.

Even after eating just one egg yolk in the morning, it’s likely you will need to restrict other animal fats from your diet for the rest of the day to keep within recommended levels.

Myth 5
My blood pressure can never be too low. — False

In general, high blood pressure — a risk factor for heart disease — is so persistent that just getting blood pressure to normal levels doesn’t happen very often.

For most people, low blood pressure is a healthy thing. However, in rare cases, when a person is ill or on blood-pressure-lowering medication, she can get truly low blood pressure, which can lead to fatigue, fainting and kidney dysfunction.

Myth 6
I’ll know I’m having a heart attack because my chest and arm(s) will hurt. — False

Although 60 percent to 90 percent of heart attacks have the common symptoms (chest pain, arm pain, etc.), 25 percent of heart attacks have either no signs or atypical signs associated with the incident. So-called “silent” heart attacks are more common in diabetics.

On average, about half of women will have traditional chest pain, and the other half show atypical symptoms such as headaches, nausea, fatigue and stomach upset.

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In this month of love, with cards and shop windows adorned with heart-shaped items surrounding us, take a moment or two to appreciate your own heart.

Each day, it works tirelessly, without ceasing, steadily keeping lifeblood flowing through the veins and arteries of each and every human being. Quietly doing its job, the heart beats an average of 3.3 billion beats in a lifetime!

And how do we thank this hardworking muscle upon which our very lives depend? For many Americans, by feeding it cholesterol, saturated fats, refined sugars, and other harmful substances lacking the nutritive value a healthy heart needs to keep going, day in and day out, and with insufficient exercise and carrying weight that strains the body s hardest-working muscle.

Cardiovascular diseases, including stroke, are the No. 1 killers in the United States, according to information from the American Heart Association. Heart health   or the lack of it, for many of us   is one reason the president annually proclaims February as  American Heart Month,  at the request of Congress.

Coronary artery disease, or CAD, is the leading cause of death in every developed country,  according to doctors Michael F. Roizen and Mehmet C. Oz, authors of You   the Owner s Manual.  Every American, Asian, and European has a   50 percent chance that his or her quality of life will be damaged by arterial aging disease.

A healthy heart pumps oxygenated blood to itself and the rest of the body, while bringing blood through organs to have toxins removed and back to the lungs for more oxygen. A heart weakened by disease or pumping inefficiently due to clogged arteries means a diminished quality of life and can lead to sudden death.

For optimum health, say Roizen and Oz, your body needs  enough physical activity (exercise) to burn between 3,500 and 6,500 calories a week (or from 500 to about 950 a day).

The American Heart Association recommends,  Don t eat more calories than you know you can burn up every day.  For heart health, the association also suggests increasing the amount and intensity of physical activity to match the number of calories you take in.

Every body also needs about an hour each week of cardiovascular activity to elevate the heart rate to 80 percent or more of its age-adjusted maximum   calculated at 220 minus one s age   for an extended period of time. This can be in three 20-minute periods each week to obtain optimum health and for living younger, according to Roizen and Oz.

Exercise can be as simple as walking or as energetic as swimming or cycling. Another benefit of exercise is to maintain a healthy weight, as extra weight increases the risk of heart disease. A good guideline to follow is to keep a waist size of less than 40 inches for men or 35 inches for women.

Engaging in enough physical activity to be slightly out of breath, or enough to break a sweat during that time, is usually sufficient to maintain heart health and a healthy weight, provided a body is not overweight to begin with.

Keeping tabs on blood pressure and cholesterol levels also helps with heart health. A healthy pressure is 115/76, according to Roizen and Oz. Take steps if the pressure is too high and be guided by a doctor about the action to take.

Genetics and diet contribute to cholesterol levels. High HDL, or healthy cholesterol, can be caused by foods containing too much cholesterol, simple carbohydrates, and trans and saturated fats, or by genetics. High LDL, the unhealthy cholesterol, can run in families.

Avoiding most  white foods,  such as white bread, refined sugar, and white pasta, along with restricting saturated and trans fats to less than 20 grams daily, can lower LDL.

Among the things Roizen and Oz suggest for increasing healthy or HDL cholesterol are consuming healthy fats, such as a tablespoon of olive oil, 4 ounces of fish, or 12 walnuts daily; walking or another physical activity for 30 minutes a day; taking niacin; and having a drink of alcohol each night. A word of caution: Too much alcohol can cause aging of the immune system.

Diet plays a huge role in heart health. A diet rich in flavonoids, such as those found in nuts, teas, red wine, grapes, cranberries, onions, and tomatoes, along with conservative amounts of monounsaturated fats, like olive oil, and fatty fish like salmon and whitefish   both high in omega-3 fatty acids, provides energy and nutrients for a healthy heart.

Other aids for a healthy heart may include a low dose of aspirin, as prescribed by a doctor. A good multivitamin can also help, and getting enough potassium from your diet, such as from melons, bananas, or avocados, is beneficial.

Choose foods like vegetables, fruits, whole-grain products, and fat-free or low-fat dairy products most often,  the American Heart Association recommends. High in vitamins, minerals, and fiber, as well as calories, a variety of vegetables and fruits can help control weight and blood pressure. Whole-grain products contain fiber, which can help lower blood cholesterol and help you feel full, which in turn may help manage weight.

Generally, a healthy heart and cardiovascular system can be maintained with a plan including a healthy, low-fat diet, moderate exercise, and regular checks on blood pressure and cholesterol.

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It may surprise you that cardiovascular disease is the number one killer of Jamaicans. Most of us hear that high cholesterol causes cardiovascular disease, but understanding cholesterol’s role in disease of the heart and blood vessels helps individuals work with their physician in choosing effective treatment.

Atherosclerosis means ‘artery hardening’ from deposits of macrophages (cells that usually help the body fight infections), fat, cholesterol, calcium, and fibrous tissue that build up in the artery lining. This build-up is known as a plaque or lesion, gradual accumulation of which leads to blockage of blood flow in arteries. Obstruction of arteries feeding the heart can lead to heart attack.

How does cholesterol cause lesions? Essentially, excess blood cholesterol deposits in artery lining and induces signals that attract macrophages to the site of cholesterol deposits. The macrophages engorge cholesterol, die and become the core of the lesion. Before dying, macrophages attract muscle cells to invade and disrupt the structure of the artery’s lining. The muscle proliferates causing the lesion to grow and bulge into the artery’s interior, making blood flow increasingly tight.

Harmful or beneficial

In truth, however, it is the protein transporting cholesterol in blood that determines whether cholesterol is harmful or beneficial. Cholesterol transported by bulky low-density lipoprotein (LDL) is what macrophages consume thereby causing lesions, whereas, smaller high-density lipoprotein inhibits atherosclerosis by transporting cholesterol out of macrophages.

Research shows numerous factors determine why some people develop atherosclerosis while others do not. Family history of naturally high cholesterol, diabetes mellitus or high blood pressure are linked to greater risk of developing atherosclerosis. These studies indicate as many as 50 per cent of patients have a genetic pre-determinant for developing the disease in the other 50 per cent or more of atherosclerosis patients, environmental risk factors, such as diets high in saturated fats and cholesterol, smoking, low physical activity and excess waistline fat, are some of the causes for atherosclerosis onset.

A compounding fact is that genetic and environmental risk factors combine to more than just an additive extent in inducing heart disease.

How each risk factor contributes to atherosclerosis varies, but one consistent player in the grand scheme is cholesterol. It is no surprise then that current drug therapies aim to lower cholesterol. Two types of prescribed drugs are statins like Lipitor, which stimulate the liver to remove LDL from the blood; and those that prevent the stomach from absorbing cholesterol, like Zetia. Since these drugs reduce cholesterol, their best candidates are patients with family history of high cholesterol who, with a low cholesterol diet, still cannot reduce their blood cholesterol enough efficient at inhibiting atherosclerosis, and therefore heart failure, the medications’ side effects of muscle pain and weakness, as well as treatment cost, are notable.

Lifestyle changes

For individuals without genetic predisposition who begin to develop atherosclerosis, there is strong argument for lifestyle changes. The Heart Foundation of Jamaica recommends a combination of physical activity, healthy weight, and nutrient-rich diets low in animal fats. These choices are sometimes enough to inhibit atherosclerosis in several ways, like lowering blood pressure and cholesterol - the benefits of which are indisputable, even in combination with cholesterol medication.

Ultimately, by staying informed so we know the right questions to ask our doctor, and with regular check-ups, we can take control of our well-being. Following these simple steps, it is within our power to change the statistics by reducing occurrence of cardiovascular disease, Jamaica’s number one killer.

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Even add reduce risk, Anyway, eating heart-healthy diet can make you smart to,having some regular activity of physical and do not smoking tobacco.

Get check your level of cholesterol astherecommandation by your doctor every five years.

If you have your total cholesterol get falls between two hundred and two hundred thirty nine mg/dL, you will have an evaluation by your about your bad cholesterol levels of LDL , your (good) cholesterol and for the end triglycerides.

That way It’s possible to get borderline-raise total cholesterol numbers add normal the bad it levels LDL compare by increasing HDL (good) cholesterol.

Create a treatment and prevention plan that’s you think right for you by working with your doctor.

To make some changes of lifestyle, by eating a diet of heart-healthy still getting regular phycal of activity, and by avoiding smoke of tabacco and is up to your (bad) LDL levels and your factor of other risk, you may need medication.

You better ask your doctor the way that you should often get your cholesterol rechecked.

In cholesterol how make hdl higher? We think person who get the level of total cholesterol of 240 mg/dL or typically get more twice the coronary heart of disease risk like person whose the level of it see desirable (200 mg/dL).

Even if your test did not let see your LDL , triglycerides,and HDL, a fasting profile you should order your doctor.

Have you already heart how to make your good cholesterol level HDL higher or to make it better. Reduce HDL cholesterol ( 40 mg/dL less for men, 50 mg/dL less for women) that can puts you at higher heart disease risk.

In the amount man, HDL levels launch from fourty to fifty mg/dL. In the amount woman, they launch from fifty to sixty mg/dL.

About HDL cholesterol of sixty mg/dL or higher offer you some protection against disease of heart.

Being sedentary, Smoking, and being overweight can all result in reduce HDL.

To increase your HDL level, One more time you ought to avoid tabacco smoke by maintainning health weight and take on physical activity at least 30-60 minutes or more days than not about the cholesterol how to make hdl higher.

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Although cholesterol drugs are in the news lately, what is getting lost in the discussion is the fact that it’s possible to lower your cholesterol without drugs. It’s just not as easy.

In fact, many doctors think dietary changes are too difficult for most of their patients. While they typically encourage better eating and a diet low in saturated fat, they also prescribe cholesterol-lowering drugs called statins as a faster way to lower bad cholesterol.

But many people can’t tolerate statins and their side effects. Others simply don’t want to take a pill every day or shoulder the cost of a prescription. For those patients, dietary changes may be a better option.

In 2006, The American Journal of Clinical Nutrition reported on a study of 55 patients with high cholesterol who, over the course of a year, started eating a diet rich in soy proteins, fiber and almonds. All those foods may have cholesterol-lowering properties. Twenty-one patients managed to lower their cholesterol by 20 percent or more by the end of the year. The researchers noted that whether the patient was motivated and actually stuck with the diet most of the time was key.

Journalist Tom Burton, a former colleague, wrote about his own efforts to lower cholesterol without drugs for The Wall Street Journal. He found that many doctors don’t really know how to advise patients about dietary changes to lower cholesterol. He found one who did and used him as a nutrition “coach” to help him figure out which changes would be most effective for him.

The problem for Mr. Burton was that he already had a pretty healthful diet. He ran four miles most days and had given up red meat and most cheese. But his bad cholesterol was 169 mg/dL — far above the 100 mg/dL most doctors recommend. Doctors were telling him statin drugs were in his future.

After documenting his eating habits, Mr. Burton was advised by his doctor to cut out a favorite dish — roast chicken with the skin on. He was told that more of his protein should come from fish, beans and nuts. He phased out the chicken as well as shrimp and squid, which are high in dietary cholesterol. He began including steel-cut oatmeal, eggplant, roasted soybeans, whole-wheat pasta and Brussels sprouts in his diet. He also increased his exercise. His cholesterol numbers were slow to move, but eventually they did, dropping 33 percent.

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While routine screening of children for high cholesterol isn’t necessary, you may want to consider it under certain circumstances.

Children should be screened if their parents, grandparents, aunts or uncles have high cholesterol or cardiovascular disease before age 55 for men and 65 for women.

Higher-than-normal blood cholesterol among children does not always predict high levels in adulthood. But for children from high-risk families, check with your doctor and work with a registered dietitian to bring cholesterol levels down.

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Lowering cholesterol drastic diet also on the response of certain treatment, there is some of simple may get together daily with exercise will do the risk, and amount natural supplement or cholesterol lowering

Person who do not answer to the steps on diet, the two diets you don’t have to take cholesterol-lowering drugs, you have to try some very –fats diet.

After eliminates these diets you most eat meats and fats, and dairy product include twenty-eight to twenty-six percent of calories from fats contain.

Having high cholesterol in your blood means leave with a greater risk enough of heart attacks, a drastic diet can help you.

The amount of every on percent high in it, in the average peoples bloods. Three is about two percent high in the risk of the heart attack.

Heart study have found is the best for decreasing cholesterol level, plant food getting no cholesterol, whereas, meats, dairy production get large amount of cholesterol saturated fats.

Even if ignored you’ve been with the atherosclerosis, you can still hope it without drugs a doctors has demonstrated that disease may be reversed, and has dangerous side effect some time.

Diet in vegetables with less than ten percent fats and some moderated exercise within a year, Starting a dissolve plaque that have been growing in their heart with decade.

By the way every body knows there is two type of cholesterol, the good cholesterol hdl, high density lipoproteins and bad one ldl low-density lipoproteins.

The first one present in the body hdl protect the heart, and the walls of the arteries against the artery disease.

You can lower it by exercising will help you to decrease your risk of heart attack.

And maintains the healthy body weigh in an amount of trans fats can be minimized by replace these with the dietary, fibre with saturated fats.

There some goods reason to get check your cholesterol, for do not lead you problems, pay intention to not have too much cholesterol in your bloods.

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Do you have high choresterol?  Taking statins?  Thinking of taking statins?

On January 17 the NYTs business section — that is right, the  business section not the health section — wrote about mounting  evidence that while statins reduce bad cholesterol there is no proof they reduce heart attacks and strokes.

For decades, the theory that lowering cholesterol is always beneficial has been a core principle of cardiology. It has been accepted by doctors and used by drug makers to win quick approval for new medicines to reduce cholesterol.

But now some prominent cardiologists say the results of two recent clinical trials have raised serious questions about that theory — and the value of two widely used cholesterol-lowering medicines, Zetia and its sister drug, Vytorin. Other new cholesterol-fighting drugs, including one that Merck hopes to begin selling this year, may also require closer scrutiny, they say.

“The idea that you’re just going to lower LDL and people are going to get better, that’s too simplistic, much too simplistic,” said Dr. Eric J. Topol, a cardiologist and director of the Scripps Translational Science Institute in La Jolla, Calif. LDL, or low-density lipoprotein, is the so-called bad cholesterol, in contrast to high-density lipoprotein, or HDL.

For patients and drug companies, the stakes are enormous. Led by best sellers like Lipitor from Pfizer, cholesterol-lowering medicines, taken by tens of millions of patients daily, are the largest drug category worldwide, with annual sales of $40 billion.  That is why this piece was in the business section.

Doctors generally believe that the amount by which cholesterol is lowered, not the method of lowering it, is what matters.

The revelation that statin cholesterol drugs may be of little benefit, as revealed in a lengthy cover story in January 28 issue of Business Week (BW) magazine continues the expose.

How can anyone question the benefits of such a drug, asks BW, when they are “thought to be so essential that, according to the official government guidelines from the National Cholesterol Education Program (NCEP), 40 million Americans should be taking them. Some researchers have even suggested – half-jokingly – that the medications should be put in the water supply, like fluoride for teeth. And it’s almost impossible to avoid reminders from the industry that the drugs are vital. A current TV and newspaper campaign for one statin drug, as endorsed by Dr. Robert Jarvik, artificial heart inventor, proclaims that this drug ‘reduces the risk of heart attack by 36%…in patients with multiple risk factors for heart disease.”

Jarvik’s claim is incorrect.   The Business Week report says statin drugs benefit only 1 in 100 users, but they claim to reduce the risk of a non-mortal heart attack by 36%. But that figure is a relative number, not a hard one. About 3% of patients taking an inactive placebo pill will experience a heart attack compared to 2% taking a statin drug, which produces the so-called 30-plus percent risk reduction. But in hard numbers, this is only a 1% reduced risk.

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It is important to follow the recommendations of healthcare professionals. High Blood Cholesterol is a high risk factor for coronary artery disease and the number one killer in the United States of America because it clogs the pipes. Cholesterol is a waxy substance found in all animal tissue, including humans, and is found in all foods that come from animal sources. Bad and good cholesterol There are two primary forms of cholesterol; low-density lipoproteins (LDLs) and high-density lipoproteins (HDLs). LDL cholesterol is considered as bad cholesterol because it tends to drop off along the way, clogging arteries and blood vessels, and contributing to plaque formation.

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