Archive for the ‘genetic’ Category

What Is Cholesterol?

Friday, June 13th, 2008

To understand high blood cholesterol (ko-LES-ter-ol), it is important to know more about cholesterol.

* Cholesterol is a waxy, fat-like substance that is found in all cells of the body. Your body needs some cholesterol to work the right way. Your body makes all the cholesterol it needs.
* Cholesterol is also found in some of the foods you eat.
* Your body uses cholesterol to make hormones, vitamin D, and substances that help you digest foods.

Blood is watery, and cholesterol is fatty. Just like oil and water, the two do not mix. To travel in the bloodstream, cholesterol is carried in small packages called lipoproteins (lip-o-PRO-teens). The small packages are made of fat (lipid) on the inside and proteins on the outside. Two kinds of lipoproteins carry cholesterol throughout your body. It is important to have healthy levels of both:

* Low-density lipoprotein (LDL) cholesterol is sometimes called bad cholesterol.
o High LDL cholesterol leads to a buildup of cholesterol in arteries. The higher the LDL level in your blood, the greater chance you have of getting heart disease.
* High-density lipoprotein (HDL) cholesterol is sometimes called good cholesterol.
o HDL carries cholesterol from other parts of your body back to your liver. The liver removes the cholesterol from your body. The higher your HDL cholesterol level, the lower your chance of getting heart disease.

What Is High Blood Cholesterol?

Too much cholesterol in the blood, or high blood cholesterol, can be serious. People with high blood cholesterol have a greater chance of getting heart disease. High blood cholesterol on its own does not cause symptoms, so many people are unaware that their cholesterol level is too high.

Cholesterol can build up on the walls of your arteries (blood vessels that carry blood from the heart to other parts of the body). This buildup of cholesterol is called plaque (plak). Over time, plaque can cause narrowing of the arteries. This is called atherosclerosis (ath-er-o-skler-O-sis), or hardening of the arteries.

Special arteries, called coronary arteries, bring blood to the heart. Narrowing of your coronary arteries due to plaque can stop or slow down the flow of blood to your heart. When the arteries narrow, the amount of oxygen-rich blood is decreased. This is called coronary artery disease (CAD). Large plaque areas can lead to chest pain called angina (an-JI-nuh or AN-juh-nuh). Angina happens when the heart does not receive enough oxygen-rich blood. Angina is a common symptom of CAD.

Some plaques have a thin covering and burst (rupture), releasing fat and cholesterol into the bloodstream. The release of fat and cholesterol may cause your blood to clot. A clot can block the flow of blood. This blockage can cause angina or a heart attack.

Lowering your cholesterol level decreases your chance for having a plaque burst and cause a heart attack. Lowering cholesterol may also slow down, reduce, or even stop plaque from building up. Plaque and resulting health problems can also occur in arteries elsewhere in the body.

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The Truth Behind The Cholesterol In Our Body

Wednesday, June 11th, 2008

Cholesterol is a lipid or a fat-like substance that the body needs for several processes. The absence or excess of it can cause an imbalance in the body.

The Importance of Cholesterol in the Body

Cholesterol is responsible for several functions in the body. Here are some of them:

1. It is used to make vitamin D. Vitamin D is synthesized using sunlight and cholesterol. This process takes place under the human skin.
2. It absorbs the fat and fatty acids from the human intestines.
3. The body produces steroid hormones using cholesterol.
There are two kinds of cholesterol that exists in the body. These are the LDL, and the HDL forms of cholesterol. LDL is used by the body to perform the above-mentioned functions. HDL, on the other hand, is used by the body to clean up the excess cholesterol in the bloodstream and tissues so that it can be disposed of.

You might wonder now, if cholesterol is actually an important part of the body, why is it linked to heart complications and disease? In the Quaker Oats commercial, it is touted to contribute to a healthy heart by removing the cholesterol in our bloodstream so it will not clog and cause heart diseases. Why is there a need to do so when cholesterol is actually needed for some bodily functions?

Causes of High LDL

In reality, LDL does not directly contribute to heart disease as we are sometimes led to believe because of misleading advertisements. The problem can only arise if the LDL levels in our blood go way beyond the norm. An excess of LDL can cause a condition known as atherosclerosis, in which cholesterol as well as other dangerous substances in the body start to build up inside the arteries. When this happens, you are mostly likely going to suffer a heart attack or a stroke.

LDL build-up in the blood can be caused by a high saturated fat diet. This happens when you consume too much butter, cream, cheese and other full-fat dairy products. Some meats and many baked, fried and snack foods also high amounts of saturated fat. It can also be found from palm or coconut oil, so it is important to note that having vegetable oil as one of the ingredients in a product does not necessarily mean it is a low fat product.

High LDL levels can also be hereditary, which means you inherit it from your family. There is nothing you can do about this, except to watch your saturated fat diet so the LDL in your body does not have to rise higher than it already is.

Ways to Lower or Maintain a Low LDL in the Blood

Obviously, we have to lower our saturated fat diet in order to maintain a low or optimal level of LDL in the body. How can we do this?

First, it would be helpful to switch to reduced-fat or low-fat diets rather than full-fat dairy foods. You should also replace solid cooking fats with unsaturated cooking oils like sunflower, soybean or olive. When eating snacks, avoid as much as possible biscuits, cakes, pastries and fried snack foods.

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Parkinson’s and Cholesterol

Wednesday, May 28th, 2008

A relationship between low levels of cholesterol and Parkinson’s has been confirmed in a follow-up study. In 2006, University of North Carolina at Chapel Hill researchers published a study that found people with low levels of LDL cholesterol are more likely to have Parkinson’s disease than people with high LDL levels.

But that study could not answer the question of whether low LDL (low-density lipoprotein) levels were present in study participants before they were diagnosed with Parkinson’s, or if they developed low LDL levels after being diagnosed.

In the new study led by UNC researchers in collaboration with colleagues in Virginia, Hawaii and Japan low LDL levels were present in a group of men of Japanese ancestry long before these men were diagnosed with Parkinson’s.

“This finding gives us one more piece in the puzzle about the role of cholesterol in Parkinson’s disease,” said Dr. Xuemei Huang, the study’s principal investigator.

“What makes these results especially useful is the fact that most of the men in this study were not taking cholesterol-lowering drugs such as statins,” Huang said. “This suggests that the association between low LDL levels and Parkinson’s exists independently from statin use, which helps answer another important question raised by our earlier study.”

The new study was published online this week by the journal Movement Disorders.

Low levels of LDL cholesterol are clearly associated with good cardiovascular health. Huang’s research adds to a growing literature indicating that people with low LDL may be at greater risk for developing Parkinson’s.

“Our study again shows an association between low cholesterol and the risk of Parkinson’s disease, but we have not shown cause and effect,” Huang said. “People taking statins for valid medical reasons should not stop simply to avoid Parkinson’s.”

For this prospective study, fasting lipids were measured from 1991 to 1993 in a group of 3,233 men of Japanese ancestry who took part in a long-running study called the Honolulu-Asia Aging Study. These data were collected before statin therapy for lowering cholesterol was widely available. When followed for about ten years, the incidence of Parkinson’s disease increased with decreasing levels of LDL cholesterol.

After adjusting their statistical analysis for age, smoking, coffee intake and other factors, the researchers calculated that the relative odds of Parkinson’s for men with lower LDL levels (85 milligrams per deciliter) was about twice that of those with higher LDL levels (135 milligrams per deciliter). They concluded that this study supports the hypothesis that low LDL levels are associated with an increased future risk of Parkinson’s.

Huang said more research is needed to confirm these findings, with logical next steps including conducting studies with larger sample sizes and that include women and African-Americans.

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Lipitor and Your Medical History

Thursday, May 15th, 2008

Everything about your past medical history can be important when a doctor weighs the advantages of prescribing Lipitor for you. Naturally, a doctor will offer you a complete medical examination before thinking of prescribing Lipitor, and will probably ask for a battery of tests as well, but it is for you to be forthcoming about any substance abuse issues that may prevail. Drinking habits are very significant when it comes to using Lipitor. Your doctor should know about all other drugs that you take, or have taken in the recent past. Mixing Lipitor with anti anxiety drugs can be dangerous.

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Cholesterol-Associated Gene Variants Can Predict Cardiovascular Events

Tuesday, April 29th, 2008

A study appearing in this week’s New England Journal of Medicine confirms that a combination of gene variants previously associated with cholesterol levels does reflect patients’ cholesterol levels and can signify increased risk of heart attack, stroke or sudden cardiac death. Led by researchers from the Massachusetts General Hospital Cardiology Division, the study’s findings are a first step towards the ability to identify individuals who might benefit from earlier use of cholesterol-lowering medications and other measures to combat elevated risk.

“The prospect of personalized medicine has received much hype, but until recently, there has been little hard evidence to support the promise,” says Sekar Kathiresan, MD, MGH Director of Preventive Cardiology, the paper’s lead author. “We feel that our data provides two insights. First, we provide a foundation for the possibility that a panel of gene variants will eventually be useful in preventive cardiac care. Second, we show that the combination of multiple variants related to cholesterol importantly contribute to the genetic risk for heart attack.”

It is estimated that about half the variation in high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol levels is inherited, rather than being caused by lifestyle factors such as diet and exercise. While studies have associated several gene variants with cholesterol levels, exactly how those variants impact the risk of cardiovascular disease is unclear. The current study was designed to explore the influence of those variants on the risk of cardiovascular events — heart attack, stroke or sudden cardiac death — and whether measuring such variants could help predict risk better than simply measuring HDL and LDL levels.

Since the effects of individual gene variants appears slight, the research team looked at a combination of 9 single-nucleotide polymorphisms (SNPs) previously associated with cholesterol levels. They analyzed data from 5,414 Swedish adults who participated in a major prospective epidemiological study and correlated data — including standard measurements of HDL and LDL cholesterol and the presence of the 9 gene variants — with information on the participants’ subsequent medical histories available from a registry of information collected on all Swedish citizens. After the initial genotyping of participants not receiving lipid-lowering therapy, participants were assigned a genotype score ranging from 0 to 18, based on how many copies of the unfavorable SNPs they carried. Of the participants who had no cardiovascular events before enrolling in the study, 238 suffered a heart attack, stroke or cardiac death during the subsequent 10.6 years.

Higher genotype scores did reflect higher LDL (”bad”) cholesterol and lower HDL (”good”) cholesterol levels. Importantly, those with genotype scores of 11 or higher had a 63 percent greater risk of a cardiovascular event than did those with scores of 9 or lower. Although testing for the panel of 9 SNPs was not better than standard risk factors for predicting cardiac events in the overall population, among participants classified at intermediate risk by standard measures, adding the 9-SNP panel significantly improved the ability to distinguish truly elevated or reduced risk levels.

“A current clinical dilemma is how early to start patients on cholesterol-lowering medications like statins that can reduce the risk of heart attack. Our data suggest that those individuals classified as higher risk based on a genetic test may deserve more intense pharmacological and lifestyle treatments,” says Kathiresan. “But before we can move from our pilot data to information that can impact the care of patients with or at risk for cardiovascular disease, we need to discover all the risk-related variants — and there will probably be 50 to 100 — and then conduct clinical studies confirming that this information can reliably guide patient care.” Earlier this year Kathiresan, an instructor in Medicine at Harvard Medical School, and colleagues from the Broad Institute of Massachusetts Institute of Technology and Harvard University began this gene-discovery process and identified six new cholesterol-associated gene variants in a separate study published in Nature Genetics.

Support for the NEJM study includes grants from the Doris Duke Charitable Foundation, the Fannie Rippel Foundation, the Donovan Family Foundation and the National Institutes of Health. Study co-authors are David Altshuler, MD, PhD, and Christopher Newton-Cheh, MD, MPH, MGH; Olle Melander, MD, PhD, Dragi Anevski, PhD, Charlotta Roos, MSc, Goran Berglund, MD, PhD, Bo Hedblad, MD, PhD, Leif Groop, MD, PhD, and Marju Orho-Melander, PhD, Lund University, Sweden; Candace Guiducci and Noel Burtt, Broad Institute; and Joel Hirschhorn, MD, PhD, Children’s Hospital Boston.

Massachusetts General Hospital, established in 1811, is the original and largest teaching hospital of Harvard Medical School. The MGH conducts the largest hospital-based research program in the United States, with an annual research budget of more than $500 million and major research centers in AIDS, cardiovascular research, cancer, computational and integrative biology, cutaneous biology, human genetics, medical imaging, neurodegenerative disorders, regenerative medicine, systems biology, transplantation biology and photomedicine.

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LDL Cholesterol Levels Associated With New Gene Locus

Saturday, April 26th, 2008

A new gene locus has been discovered that may be associated with levels of low-density lipoprotein (LDL) cholesterol in the blood. This new finding may aid the development of new drugs to fight cardiovascular disease, according to an article published in the February 9 issue of The Lancet.

Higher LDL cholesterol concentrations have been linked to cardiovascular diseases, and in previous studies, a clinical benefit can be reaped by lowering concentrations of LDL cholesterol in the blood. This means that improving understanding of the biological mechanisms that control the metabolism and regulation of LDL cholesterol could provide valuable information for identification of new therapeutic directions.

Dr Manjinder Sandhu, Department of Public Health & Primary Care and MRC Epidemiology Unit, University of Cambridge, UK, and colleagues did performed an association of LDL cholesterol levels with genome-wide data from 11,685 participants in five separate studies.

The researchers found evidence that correlation existed between LDL-cholesterol levels and the chromosome region 1p13.3. Across all of the studies examined, this association maintained its magnitude and showed independent statistical association in each study. The authors conclude with optimism for the implications of this result: “These results potentially provide insight into the biological mechanisms that underlie the regulation of LDL cholesterol and might help in the discovery of novel therapeutic targets for cardiovascular disease.”

Dr Ronald Krauss, Children’s Hospital Oakland Research Institute, Oakland, CA, USA, contributed in an accompanying comment with more options for further investigation: “In addition to the identification of new treatment targets, the discovery of genetic polymorphisms that affect LDL and other markers of cardiovascular disease risk could provide a means to categorise specific phenotypes that might merit different treatments and to identify at-risk individuals.”

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Gene Locus Linked to LDL Cholesterol Levels

Monday, April 21st, 2008

A new gene locus has been linked with LDL cholesterol levels, opening the door to research into potential new targets for the treatment of hypercholesterolemia, according to research published in the Lancet.

Here are some recommendations regarding LDL cholesterol goals from the National Cholesterol Education Program (NCEP):

•    For high risk patients, defined as those with coronary heart disease (CHD) or CHD risk equivalents and a 10-year risk >20%, LDL goal is <70-100 mg/dL.

•    For moderately high risk patients, defined as those having two or more CHD risk factors  and a10-year risk of 10% to 20% as well as moderate risk patients, defined as those with two or more risk factors and a 10-year risk under 10%, LDL goal is <130 mg/dL.

•    For lower risk patients, defined as those with no or only one risk factor, LDL goal is <160 mg/dL.

Researchers from the University of Cambridge conducted a genome-wide association study of LDL cholesterol concentrations using genetic data collected from nearly 12,000 people in five studies. They identified a link between LDL cholesterol and the chromosome region 1p13.3. The degree and independence of the association between this locus and LDL cholesterol was similar across all five studies.

Based on these findings, the authors conclude that the chromosome region 1p13.3 plays a role in the biological mechanisms that underlie regulation of LDL cholesterol. This research highlights the discovery of a potential new biological target for the development of drugs to treat elevated LDL cholesterol. Better understanding of the genetics underlying hypercholesterolemia may also lead to the ability to identify at-risk individuals.

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Gene Linked to Development of High LDL Cholesterol

Friday, April 18th, 2008

A new gene has been linked with the tendency to develop a high concentration of LDL or “bad” cholesterol in the blood, according to research published in the Lancet.

Here are some facts about LDL cholesterol:

•    Having high levels of LDL cholesterol in the blood is a major cause of coronary heart disease (CHD), and therapies that lower LDL cholesterol reduce this risk.

•    Your doctor can check your LDL cholesterol level and let you know if you need to try to reduce it through lifestyle change and/or drug therapy. The higher your LDL cholesterol and the more other risk factors for CHD you have (such as smoking and high blood pressure), the more likely you are to be prescribed medication.

•    Lifestyle changes that can help lower your LDL cholesterol include reducing the amount of saturated fat and cholesterol you eat, increasing your physical activity, and controlling your weight.

Researchers from the University of Cambridge examined the genetic makeup of nearly 12,000 people and looked to see whether they could find any associations between their genes and their LDL cholesterol levels. They found a link between the participants’ LDL cholesterol levels and a gene known as 1p13.3.

Based on these findings, the authors conclude that the 1p13.3 gene plays a role in how the body handles LDL cholesterol in the body. This gene and its effects on the body, therefore, could be potential targets for the development of new drugs that treat high cholesterol and heart disease. In addition, a better understanding of how genes affect cholesterol levels can help identify individuals who are at high risk for developing these serious conditions.

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How to Lower Your Cholesterol

Wednesday, April 9th, 2008

Heart disease is the UK’s biggest cause of death - and having high cholesterol puts you at significant risk. But as there are no obvious symptoms, a heart attack is often the first warning sign of the condition.

Don’t let this happen to you. Take our quick cholesterol quiz to identify whether you may have the condition - and how to slash your risk…

1. How old are you?

a) Under 24 (-1)
b) 25-44 (0)
c) 45-65 (+1)
d) Over 65 (+2)

Why it matters: Cholesterol increases with age. Only 26 per cent of men and 31 per cent of women under 25 have high cholesterol, but by the age of 50 those figures shoot up to 81 per cent of men and 79 per cent of women. “We don’t exercise as much as we get older and we tend to eat more fat,” explains Ellen Mason, cardiac nurse at the British Heart Foundation.

Whatever your age simple lifestyle changes can turn things round fast. Just adding a handful of walnuts a day to your diet can slash levels of harmful LDL cholesterol by 10 per cent in up to six months, while eating 100g of beans daily can reduce it by 20 per cent in three weeks.

2. Do your relatives have high cholesterol? Or have any close male relatives had a heart attack before 50, or any female ones before the age of 55?

a) Yes (+2)
b) No (0)
c) I have no idea (+1)

Why it matters: “Family history is definitely a risk factor for cholesterol,” says Dr Robert Finnie, a trustee for the cholesterol charity Heart UK.

“If a sibling or parent has high cholesterol you have a 50 per cent greater chance of having it yourself.” The reason is that genes can determine how your body makes and processes cholesterol. If, for example, you inherit an under-performing version of a gene called APOE-4, you won’t transport cholesterol out of your body as well as other people.

Fortunately, gene behaviour can be changed. According to Dr Jack Challam, author of Feed Your Genes Right (Wiley Books), healthy levels of vitamin E in the diet help boost APOE-4 activity. Consider taking a supplement.

3. Which of these sounds most like your exercise regime?

a) I don’t do any (+2)
b) I do my 10,000 steps throughout the day (+1)
c) I exercise for 20 minutes at least three times a week (0)
d) I exercise for more than 20 minutes at least three times a week (-1)

Why it matters: “Exercise triggers the release of enzymes that break down the harmful LDL form of cholesterol that collects in your arteries,” says Dr Marie Murphy, head of the School of Exercise Sciences at the University of Ulster. Any movement triggers this enzyme release - in Dr Murphy’s trials simply walking up stairs for two minutes up to eight times a day slashed LDL levels by seven per cent in eight weeks. But longer sessions of formal exercise create a greater effect.

Aim to do a 40-minute workout three to four times a week.

4. Which of these do you eat more than three times a week?

a) Red or processed meats (+1)
b) Butter, cheese, full fat milk (+1)
c) Cakes, biscuits, chocolate, crisps (+1)
d) Deep-fried foods (+1)

Why it matters: All of these are high in saturated fat. “This is basically the raw material your body needs to make cholesterol,” says nutritionist Dale Pinnock (www.dalepinnock.com).

Cut your intake of saturated fat and cholesterol levels fall.

A us study has shown that every one per cent of saturated fat you drop from your diet cuts your cholesterol by one per cent, too.

To cut down, limit all of the above and opt for low-fat versions. Grill, bake or steam foods and use heart-healthy sunflower or olive oil for frying.

5. How stressful is your life?

a) Very, I get stressed easily and it happens a lot (+2)
b) Very, but I do lots of relaxation/ exercise to fight it (+1)
c) I usually cope well with stress (0)

Why it matters: Dr Andrew Steptoe, at University College London, found that levels of “bad cholesterol” are three times higher in people who are stressed than those who remain cool under pressure. “Blood fats, including cholesterol, are released during stress as, in past times, we needed them to fuel our ability to flee the thing causing us stress. Today we tend not to run away from stresses so the fats are not used up and remain in our blood,” he says. Controlling stress is therefore important for controlling cholesterol levels.

6. How many of these do you have more than four times a week - tea, wholegrains, oats, beans, soy, olives, seeds, Benecol, nuts, apples?

a) None (+2)
b) 1-2 (0)
c) Over 2 (-1)

Why it matters: “These foods can all actively lower levels of cholesterol in your body,” says Dale Pinnock. High-fibre foods such as oats, wholegrains and beans absorb cholesterol in the intestine helping you pass it out of the system. Healthy fats in nuts, seeds and olives speed up how fast your liver breaks it down. Try to include one to two servings of cholesterol lowering foods every day.

7. How much coffee do you drink a day

a) Fewer than four cups (0)
b) Over four cups of espresso or cafetiere coffee (+1)
c) Over four cups of any other type (0)

Why it matters:
“Cafestol, an oil in coffee beans, activates an enzyme that inhibits cholesterol breakdown,” says Professor David Moore, of Baylor College of Medicine in Texas. Drinking five cups of high-cafestol coffee - espresso or that made in a cafetiere - can raise cholesterol by up to eight per cent in four weeks. Fortunately for coffee lovers a sensible intake of under four cups a day won’t cause major issues.

8. Measure the area around your tummy. Is it over 37ins (men) or 32ins (women?

a) Yes (+1)
b) No (0)

Why it matters: The more you weigh, the higher your cholesterol is likely to be.

Denise Armstrong, at Heart Research UK, says: “People who are overweight tend to eat higher fat diets and do less exercise.”

Changing these things will reduce weight - and cholesterol.

9. How much alcohol do you drink a day?

a) Nothing (+1)
b) Up to two units a day for women, up to three for men (0)
c) More than two units a day (women) or three for men (+1)

Why it matters: Moderate alcohol intake actually boosts levels of healthy HDL cholesterol. Excess alcohol doesn’t raise cholesterol, but it does increase the amount of harmful fats called triglycerides which damage the arteries.

10. Do you smoke?

a) No (0)
b) Yes (+1)

Why it matters: Smoking doesn’t increase cholesterol but it also raises triglycerides in your body.

WHAT THE SCORES MEANS

Under 3: You are living a low-cholesterol lifestyle so chances are your levels are within the normal range. Keep it up.

4-10: You may have health issues. Ask your GP for a cholesterol test, or try a home test (Superdrug’s Self-Check Test is £9.99).

More than 11: You are at high risk of high cholesterol. See your GP for a test rather than trying a home one. If levels are very high, you may need a course of cholesterol-lowering drugs - as well as making lifestyle changes.

I got a wake-up call before it was too late

Sarah Wade, 34, lives in East London. She’s single and works for a design agency. She says:

“I was registering with a new GP so I asked him to give me an MOT.”

“Although I’d lost an uncle to heart disease and my mum has high cholesterol, I was still shocked when he said my levels were high, bordering on very high. I thought cholesterol only affected overweight people and at 9st I certainly wasn’t that.”

My doctor explained some simple changes I could make to lower it. Now, one Sunday a month, I cook loads of pasta, lean meat and oily fish dishes (the omega 3 fats help lower cholesterol) and freeze them in batches. I work long hours and used to rely on ready-meals and takeaways, which are packed with saturated fats, but now I have my own healthy ready-meals.

“I eat more fruit and veg and have replaced squashes with fresh juice, especially pomegranate juice, which is good at lowering cholesterol. I eat more fibre and take psyllium husk supplements, a natural source of dietary fibre. I also run three times a week and have reduced my alcohol intake.”

“Thankfully my cholesterol is now normal. I’m just grateful I had a wake-up call before it was too late.”

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2 New LDL Cholesterol Genes Found

Saturday, April 5th, 2008

Genes Affect Levels of LDL “Bad” Cholesterol, Study Shows

An international team of scientists today announced its discovery of two genes that affect LDL (”bad”) cholesterol levels.

Those genes might make good targets for new drugs that lower LDL cholesterol, the researchers report.

Meanwhile, here’s what you can do about your cholesterol while scientists put together pieces of the puzzle:

* See where you stand. If you don’t know your cholesterol levels, all it takes is a simple blood test.
* Learn the goals. Ideally, total cholesterol should be below 200 mg/dL, LDL cholesterol below 100 mg/dL, and HDL (”good”) cholesterol 60 mg/dL and above.
* Make a plan. A healthy diet, an active lifestyle, and medications (if needed) can make a big difference in your cholesterol levels. Talk to your doctor to interpret and improve your cholesterol numbers.

LDL Cholesterol Genes

The new cholesterol genes were found by researchers including Manjinder Sandhu, PhD, of England’s University of Cambridge.

They studied DNA from more than 11,600 people in five studies. Two neighboring locations on a certain chromosome (chromosome 1p13.3) were linked to LDL cholesterol levels.

One of those locations is close to the PSRC1 gene. The other is close to the CELSR2 gene. Neither has been linked to lipid levels before.

That same stretch of chromosome 1p13.3 affects the odds of developing coronary artery disease, note Sandhu and colleagues.

But if your LDL cholesterol is too high, don’t blame it just on those two genes.

Many genes are involved in LDL cholesterol. The two newfound genes only account for about 1% of the variation in LDL levels among study participants. And cholesterol isn’t just about genes; diet and exercise also make a difference.

Sandhu’s team only had access to DNA samples from people of European descent. More diverse studies are needed, notes editorialist Ronald Krauss, MD.

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