Ibuprofren Causing Migraine
Ibuprofen is an effective treatment for acute migraine. Most of the trials were methodologically flawed and can only tell us that ibuprofen works and not how well it works. Ibuprofen at doses ranging from 400 to 1200 mg provided significantly better pain relief than placebo in three out of four placebo controlled studies.
Ibuprofen is in a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Ibuprofen works by reducing hormones that cause inflammation and pain in the body. Ibuprofen is used to reduce the fever, pain, inflammation, and stiffness caused by many conditions, such as osteoarthritis, rheumatoid arthritis, and abdominal cramps associated with menstruation.
Migraine is a very particular type of headache, often associated with systemic feelings of illness, that affects a large percentage of the world’s population. The cause of migraine is still uncertain. Current evidence suggests that dilatation of the blood vessels around the brain is likely to be important. The mechanism of action of ibuprofen in relieving migraine headache is also unclear but is most likely related to inhibition of prostaglandin synthesis in the CNS.
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